主讲人：裴永珍

讲座时间：2023年12月22日14:00

讲座地点：腾讯会议（443537914）

主办单位：数学学院

题目：

Optimization therapy by coupling intermittent androgen suppression with impulsive chemotherapy for a prostate cancer model

摘要：

Intermittent androgen suppression (IAS) plus chemotherapy with the residual effect of chemotherapy in pulsed pattern has become an indispensable clinical scheme for prostate cancer,which is presented to describe the transformation mechanism for three kinds of cancer cells. We formulate the optimal problems which represent the efficiencies of both IAS and chemotherapy in suppressing relapse of prostate cancer.Then by a proposed optimal algorithm,numerical simulations are implemented not only to show the optimal durations of on- and off-treatment and chemotherapy dosages but also to present the effectiveness of different strategies in inhibiting the relapse for three types of patients.Results reveal that the optimal IAS scheme with alterable treatment cycles is pivotal for type I and II patients.Furthermore,optimal hybrid schedule even averts the relapse of prostate cancer for type Il and IlI patients.Finally,comparing the prostate specific antigen under IAS schedule with residual effect of chemotherapy to one without residual effect of chemotherapy demonstrates the validity of both our model and algorithms in lessening the prostate specific antigen and decreasing the chemotherapy dosages.

报告人简介：

裴永珍，教授，博士生导师，天津工业大学理学部副主任，中国数学会生物数学专业委员会常务委员，天津市工业与应用数学学会副理事长。荣获天津市教学名师、入选 “天津市高校学科领军人才培养计划”主要从事生物动力系统和生物信息研究，发表论文 100 余篇，SCI检索 70 多篇。主持国家自然科学基金项目4项。